Clinical Immunology and Rheumatology is a super-speciality branch of General medicine. It deals with various diseases occurring due to autoimmunity i.e “misdirected immunity”. These diseases can affect anyone and any part of body. In local language it is called as “arthritis, Sandhivaat, Aamvaat”. Rheumatologist is the physician who specialises these diseases. With early detection, advanced diagnostic facilities and tailored therapy, good and successful results are achievable. Special emphasis are given to pregnancy, child and elderly patients. There is growing awareness in our society regarding such diseases and treatment availability. Hence, incidence of joint deformities and complications are reducing. Multi-disciplinary treatment hastens recovery specially in complicated cases. In short, early consultation with good drug compliance will have smooth and uneventful recovery.