Lymphocytosis: Symptoms, Causes, Diagnosis & Treatment

Lymphocytosis
KLE Doctor

Medically Reviewed by Dr. Abhilasha S , Pediatric Hemato Oncologist

Written by KIE Editorial Contributors

3.5 min read | Published On: 08-10-2025

Lymphocytosis: What Your Body Is Trying to Tell You

Lymphocytosis

Lymphocytosis means that your blood has more lymphocytes than usual. Lymphocytes are white blood cells. They help the body fight off infections. When these cells go up quickly, it usually means your immune system is working to protect you. Adults usually have lymphocytosis if they have over 4,000 lymphocytes in each microliter of blood. Most of the time, this happens because of short illnesses. Sometimes, it can be a sign of a more serious problem, like blood cancer or an ongoing disease.

How Common Is Lymphocytosis?

Lymphocytosis happens often. It can affect people in these situations:

  • After recovering from an infection, like a cold or the flu
  • If they have a disease that causes long-term swelling or pain, like rheumatoid arthritis
  • When starting a new medicine that changes blood cells
  • Following a big illness or serious injury
  • After having the spleen removed
  • If they get blood cancers, such as leukemia or lymphoma

Reasons for High Lymphocyte Levels

Infections

Most people get lymphocytosis because they are fighting off germs. Viruses often cause this, including:

  • Mononucleosis (Epstein-Barr virus)
  • CMV (cytomegalovirus)
  • Flu (influenza)
  • Hepatitis
  • Chickenpox or shingles
  • HIV

Some bacterial illnesses, like whooping cough, and certain parasites can also cause higher levels.

Blood Cancers

Sometimes high lymphocytes mean there is cancer in the blood or lymph system:

  • Chronic lymphocytic leukemia
  • Acute lymphoblastic leukemia
  • Non-Hodgkin lymphoma
  • Large granular lymphocytic leukemia

Other Causes

Other things that can cause high lymphocyte counts are:

  • Smoking or high stress
  • Allergic reactions to medicines
  • Diseases where the immune system attacks the body itself
  • Not having a spleen

What Are the Symptoms?

Most people do not feel any symptoms just because their lymphocyte count is high. Instead, symptoms come from the illness causing the problem. These symptoms can include:

  • Swollen lymph nodes
  • Fever or tiredness that does not go away
  • Night sweats
  • Weight loss (in serious cases)

Many times, lymphocytosis is found when the doctor does a blood test for another reason.

How Is Lymphocytosis Diagnosed?

Doctors check for lymphocytosis by:

  • Asking about your health history and doing an exam
  • Ordering a blood test called a complete blood count (CBC)
  • Sometimes doing more tests, like a bone marrow biopsy, if needed

You might see a blood specialist if the reason for lymphocytosis is not clear.

Treatment

The treatment depends on what is causing the high lymphocyte count:

  • If an infection is the cause, the blood usually returns to normal once you get better
  • If there is cancer, treatment might include medicines like chemotherapy
  • If a medicine or other illness is causing lymphocytosis, doctors may change or stop medicines, or treat that illness

Prognosis

Most people get better once the problem is treated. It is important to have regular check-ups to make sure the blood is back to normal and to catch any issues early.

Can Lymphocytosis Be Prevented?

You might not be able to prevent lymphocytosis, but the chance of getting it can be lowered by:

  • Staying away from people who are sick
  • Washing your hands often
  • Cleaning surfaces that are touched a lot
  • Living a healthy lifestyle with good food and enough rest

Find Doctors who treat Lymphocytosis

Get in Touch with a Doctor

Frequently Asked Questions

Yes, in many cases, lymphocytosis resolves naturally once the underlying infection or inflammation improves. However, if it persists for a long time, it’s important to see a doctor for further evaluation.

No, most cases of lymphocytosis are caused by temporary infections, not cancer. Only in a few cases does it signal a blood or lymphatic cancer, such as leukemia or lymphoma.

If you experience symptoms like night sweats, unexplained weight loss, fever, or swollen lymph nodes for an extended period, you should consult a doctor. These signs could indicate a more serious condition.

Doctors typically detect lymphocytosis during a routine blood test known as a complete blood count (CBC). If the results show elevated lymphocytes, additional tests may be recommended to identify the cause.

You should start by visiting a general physician. If the cause appears complex or blood-related, you may be referred to a hematologist, a doctor who specializes in blood disorders.

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