Zika Virus: Symptoms, Treatment and Prevention

Zika Virus
KLE Doctor

Medically Reviewed by Dr. Ankitha Teja Narayan, Internal Medicine

Written by KIE Editorial Contributors

3.5 min read | Last Updated: 01 August 2025 | Published On: 26 August 2023

Fever, rash, and joint pain are signs of Zika Virus infection. This mosquito-borne illness has raised global concern due to its impact on adults and unborn babies. If you’re travelling to tropical regions or experiencing unusual flu-like symptoms, it may be the early signs of Zika, and taking the necessary steps for protection is crucial. It covers how Zika spreads, its symptoms, treatments, and proven prevention methods to safeguard you and your family.

This mosquito-borne illness has raised global concern due to its impact on adults and unborn babies. Zika virus in adults usually causes mild symptoms, but in some cases, it can lead to complications like Guillain-Barré syndrome.

What is the Zika Virus?

Zika Virus is a mosquito-borne viral infection caused by the Flavivirus genus. It was first identified in Uganda in 1947 and has since caused outbreaks in Africa, Southeast Asia, and the Americas. The infection is primarily linked to the Zika virus, which is caused by mosquito bites from Aedes aegypti and Aedes albopictus. Although many cases are mild, Zika gained attention due to its association with genetic disabilities, especially microcephaly in newborns.

Zika Virus Symptoms

Symptoms usually appear 3–14 days after exposure and may persist for up to a week. Some people experience asymptomatic infection.

  • Mild fever
  • Skin rashes
  • Joint pain and muscle aches
  • Red eyes (conjunctivitis)
  • Headache and fatigue

Meaning they never develop noticeable Zika virus symptoms, but can still transmit the virus.

Zika Virus Causes

The most common Zika virus causes include bites from infected Aedes mosquitoes, which are active during the day. Additional causes and transmission routes include:

  • Maternal-fetal transmission during pregnancy
  • Unprotected sexual contact with an infected partner
  • Blood transfusion from an infected donor
  • Laboratory exposure in rare cases

The virus is not spread through casual contact, such as hugging or sharing food.

Diagnosis of Zika Virus

Diagnosing the Zika Virus requires clinical evaluation and laboratory confirmation:

  • Assessment of travel history to areas with outbreaks
  • Physical examination for rash, fever, and conjunctivitis
  • Blood and urine tests for Zika RNA (RT-PCR)
  • Serological tests to differentiate from dengue or chikungunya

Early test results are crucial for pregnant women to prevent complications in the baby.

How Zika Virus Spreads

Zika primarily spreads through bites from infected Aedes mosquitoes. Other modes include sexual transmission, blood transfusion, and from mother to fetus during pregnancy. The virus is most contagious in the first week of infection. Avoiding mosquito-prone areas and using repellents can significantly reduce the risk of Zika virus transmission bites.

Zika Virus Treatment Options

Currently, there is no specific antiviral treatment for the Zika virus. Management of supportive care:

  • Hydration and rest
  • Advanced pain relievers (avoid aspirin in children)
  • Monitoring for complications, especially during pregnancy

Patients with severe illness or high-risk conditions should seek medical care immediately.

Zika Virus Prevention

Prevention is the most effective strategy since vaccines are still under research. Key steps include:

  • Using insect repellents and wearing long clothing during an outing
  • Installing window screens and eliminating standing water
  • Avoiding travel to high-risk areas during pregnancy

The practices are vital for preventing the Zika virus and protecting against complications, such as risks to pregnancy associated with the Zika virus.

Risk Factors for Zika Virus Infection

  • Geographic Location

    • Living in and or travelling to tropical and subtropical regions where Aedes mosquitoes thrive
    • Regions with reported Zika outbreaks (South America, Central America, Caribbean, Southeast Asia, Pacific Islands)
  • Pregnancy

    Pregnant women are at the highest risk due to the possibility of congenital Zika Syndrome and microcephaly in newborns.

    Zika virus pregnancy complications include a high risk of congenital Zika Syndrome and microcephaly in newborns.

  • Unprotected Sexual Contact

    • Sexual transmission from an infected partner
    • Higher risk if the male partner was infected recently, as the virus can persist in sperm for weeks or months
  • Exposure to Aedes Mosquitoes

    • Outdoor activities during daytime, especially mornings and evenings
    • Areas with stagnant water where Aedes aegypti and Aedes albopictus breed
  • Lack of Immunity

    • People with no prior Zika infection or immunity are more susceptible
    • Newborns and infants have no natural immunity
  • Medical and Travel‑Related Factors

    • Receiving blood transfusions in outbreak regions
    • Healthcare and laboratory workers exposed to Zika samples

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Frequently Asked Questions

Most infections clear within 1–2 weeks, but the virus can persist longer in body fluids such as semen. People are advised to follow medical guidance on sexual precautions after infection.

Yes, in most cases, Zika Virus symptoms resolve on their own within a week or two without any specific treatment.

Yes, most people fully recover from the Zika Virus without long-term health issues. Severe complications are rare but can occur in newborns and people with neurological conditions.

For most adults, effects are temporary. However, babies infected during pregnancy may face lifelong neurological and developmental challenges, such as microcephaly.

No, only certain species of Aedes mosquitoes, mainly Aedes aegypti and Aedes albopictus, are capable of transmitting the Zika Virus.

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